Fresh analysis suggests that people who discontinue new GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who halt conventional diet and exercise plans.
Research printed in a prominent medical journal shows that while overweight people can lose a large proportion of their body weight while undergoing treatment, the mass returns at an average rate of 0.8 kg per month after stopping.
"People using such treatments should be aware of the danger of fast rebound weight gain when the medication is stopped," warns expert Dr. Susan Jebb.
This pace of recovery suggests a return to starting weight within about a year and a half.
Weighing Treatments
The study, which reviewed dozens of trials involving thousands of patients, compared the effects of GLP-1 agonists with older methods.
Researchers note that people who lose weight through diet and exercise generally have a more gradual weight regain—perhaps 100 grams monthly—post-intervention.
Understanding the Rapid Regain
Doctors propose the mode of action of the jabs is key to understanding the accelerated regain.
The injections mimic a body's own chemical called GLP-1, which moderates appetite.
"Long-term administration of the hormone concentrations far above than normal might result in the system to produce less of its own natural GLP-1, and could reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this hormone supplement results in hunger is no longer kept in check, making excessive eating much more probable."
A Lifelong Disease?
Health authorities advise the injections for individuals with weight-linked health risks, accompanied by prescribed lifestyle changes.
Many experts argue that, considering the significant potential of weight regain, the treatment is often long-term.
This view is reinforced by pharmaceutical companies, who note that the results "emphasize the persistent nature of obesity," similar to managing conditions like hypertension.
User Testimonies
Individuals who have stopped the medication report a intense return of hunger.
"It was like a trigger that goes on and I was suddenly ravenous," said an individual.
This difficulty is compounded if users have not established permanent lifestyle or habit changes during treatment.
Growing Interest
Recent estimates show that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is higher among females than men.
- The 40s and 50s demographic shows the greatest usage rates.
- Many access the medications through private prescriptions rather than public health services.
Ultimately, experts caution that while the jabs are effective agents for shedding pounds, they are not a magic fix and lasting health benefits hinges on integrated behavioural management.
